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A study has postulated that muscle injury in an older person combined with immune aging would cause secondary damage to healthy muscle from aberrantly migrating neutrophils, resulting in myocyte damage and apoptosis and loss of muscle fibers, which could result in functional loss and physical weakness associated with frailty (175)

Kawagishi et al

doi: 10.1186/s12905-023-02291-6 145

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Glutathione is often dubbed the body's master antioxidant due to its pivotal role in neutralizing free radicals and protecting cellular integrity

This system is especially relevant for conditions involving mitochondrial dysfunction or redox imbalance, such as Leigh syndrome or cyclin-dependent kinase-like 5 ( CDKL5 ) deficiency disorder, where impaired OXPHOS, altered mitochondrial dynamics, and increased glycolytic reliance have been documented [12, 86, 87]