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The Dietary Supplement Health and Education Act legislation enacted in 1994 stipulating that the FDA must regulate dietary supplements as food, so they are not subject to premarket approval or the same effectiveness and safety testing required for drugs left the industry largely unregulated

In an in vivo mouse model of septic cardiomyopathy induced by intraperitoneal injection of lipopolysaccharide, ZJ01 showed a cytoprotective effect, upregulated Nrf2 protein nuclear accumulation, and markedly suppressed the abovementioned cytokine levels in cardiomyocytes (Jiang et al

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

DOI: 10.15406/jdvar.2017.05.00148 13

Maffei S, De Felice C, Cannarile P, Leoncini S, Signorini C, Pecorelli A, Montomoli B, Lunghetti S, Ciccoli L, Durand T, Favilli R, Hayek J (2014) Effects of -3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome

Table 1: Adapted from Holland 2006 [3]