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Curr Opin Obstet Gynecol

(1999a) reported results supporting nephrotoxicity in kidney cancer patients

BCAAs make up ~35% of the essential amino acids in the blood ( BCAAs travel across the plasma membranes utilizing the heterodimeric transporter Slc7a5/Slc3a2

This increased activity of the Na + K + pump necessitates greater ATP consumption, which is facilitated by an enhanced aerobic glycolysis potential, and thus increased LDH activity