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The search included articles published between 2010 and 2025, using keywords: Parkinsons disease, -synuclein, dopaminergic degeneration, ferroptosis, deep brain stimulation, stem cell therapy, and AI in PD diagnosis. Results: The review highlights a multifactorial etiology involving -synuclein pathology, oxidative stress, mitochondrial dysfunction, genetic mutations (SNCA, LRRK2, VPS35), environmental toxins, and gut dysbiosis

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The Medicago PDF2 , PPRrep , and Ubiquitin genes were used as reference for the study (S1 Table in S2 File)

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Q5: How long will it take to see results

Inhibition of immune checkpoints and vascular endothelial growth factor as combination therapy for metastatic melanoma: an overview of rationale, preclinical evidence, and initial clinical data