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Safety and tolerability of the hexadecapeptide AOD9604 in humans. J Endocrinol Metab 3(12):715

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT) an enzyme linked to metabolic rate regulation, fat storage, and cellular energy balance

N Engl J Med

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Reduced lipogenesis and increased lipolysis in white adipose tissue Research demonstrated that NNMT inhibition by 5-Amino-1MQ reversed diet-induced obesity in mice, with significant reductions in body weight and white adipose tissue mass without affecting food intake

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