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Current standard of care is based on the four out of five rule [103], which indicates that four out of five of the following criteria are enough to establish CD diagnosis: (1) typical signs and symptoms (diarrhea and malabsorption)

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

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Spirometry at diagnosis and overall survival in non-small cell lung cancer patients

King et al, 2012)