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The oxidation reaction is mediated by CYP2D6

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Similarly, alterations in lipid metabolism, particularly related to omega-3 FAs, have been linked to changes in complement cascade protein expression in microglia and exacerbated spine phagocytosis (Madore et al., 2020)

Similarly, in GV-stage mouse oocytes exposed to vitrification, there is an accumulation of mitochondrial ROS and an elevated rate of apoptosis, both of which are closely associated with mitochondrial dysfunction (47)

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siRNA was transfected using Lipofectamine 2000 TM Transfection Reagent (Thermo Fisher Scientific) according to the manufacturers protocol