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In conclusion, recent research underscores the diversity of colorectal cancer (CRC), highlighting its potential as a natural tumor-suppressing process and a targetable pathway to overcome therapeutic resistance

Chakraborty, P., Nattel, S

However, this assumption is speculative and needs further study

Reactive oxygen species bind to proteins/DNA resulting in inflammation and cell damage

This regenerates NAD + to sustain ongoing glycolysis, particularly under hypoxia, while simultaneously clearing intracellular protons (H + ) to mitigate acidosis, as observed in the TME