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While animal studies have reported modest lifespan extensions and some effects on aging-related biomarkers, these findings have not been validated in rigorous human clinical trials

Notwithstanding the impressive results that have been published to date, there is still a requirement for successful human trials to be completed prior to clinical translation

Read review Dihexa for Migraine & Chronic Migraine The May 2024 NICE TA973 atogepant (Aquipta, AbbVie) approval, the rimegepant / erenumab / galcanezumab / fremanezumab / eptinezumab CGRP pathway, 2025 chronic-migraine hippocampal atrophy & accelerated brain ageing research, the Tanure BDNF-elevated-in-attack paradox, NICE NG150, and the ~10 million UK migraine population

This is important because, as you age, your body produces less and less of this helpful material