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To address these shortcomings, we incorporated hydrogels, which confer advantages such as enhancing liposomal stability, prolonging residence time on the skin surface, reducing the degradation, and ease of application 25,26

Regarding the safety of anti-TNF- agents, skin reactions (such as eczematous and psoriatic rashes) are most common [296, 297]

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Addition of sources of iron and sulfur, as well as dithiothreitol as an antioxidant have been shown to be beneficial, and systematic characterization of their effects in ADP1 could further improve the activity [32]