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NETosis is induced dependent on ROS, which majorly originates from nicotinamide adenine dinucleotide phosphate oxidases, whose activation is dependent on an elevation in cytoplasmic Ca 2+ concentration and occasionally on ROS generation in the mitochondria (144)

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The exact contribution of immunity factors in the antiviral effect of these drugs needs to be further explored, and whether this general concept can be translated in vivo has to be determined