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Methane-dominant SIBO (now often referred to as IMO - intestinal methanogen overgrowth) is more often associated with constipation

Bao YY, et al

These changes predominantly affected pathways involved in inflammatory responses, cytokine production and macrophage activation

doi: 10.1038/mp.2015.67

MBD 1 and p62 have been reported to inhibit ROS and promote tumor growth and drug resistance by inducing Nrf2 accumulation, nuclear translocation and activation

Perhaps two of the more significant omissions are the hypotheses that 1) more than one mutation may be required to initiate and promote cancer, and 2) not all genetic defects result in cancer