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Moreover, a higher absorption rate leads to a lower dosage of active constituents to exert a biological effect, as well as polar phytoconstituents (105)

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328 Covalent conjugation of targeting ligands, and/or polymeric materials such as PEG chains, carboxymethyl cellulose, dextran could distinctively facilitate the transport of IONPs across the BBB

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In addition, the presence of CKD increased cardiovascular risk and mortality in patients with diabetes