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MGO leads to cell cytotoxicity in high concentrations through reaction with nucleotides, phospholipids, and proteins [50, 51], resulting in the formation of advanced glycation end products (AGEs) and reactive oxygen species (ROS) via AGEs or non-enzymatic reaction with hydrogen peroxide [52]

Designing mesoporous silica nanoparticles to overcome biological barriers by incorporating targeting and endosomal escape

J Exp Med (1992) 176(4):103341

Free Radic Biol Med 223325340:223325

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Professional phagocytes, such as neutrophils, contain NADPH-oxidase that generates huge amounts of superoxide for microbicidal purposes