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Some strains also contain smaller pieces of DNA (110 kbp), termed pathogenicity islets. Expression of genes of PAIs is regulated by the transcription factors located on the island or externally (off the island) (Hallstrom and McCormick, 2014)

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However, when these cellular defenses become overwhelmed by chronic inflammation, viral persistence, or environmental triggers, they can create symptoms throughout the entire body

Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis