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Furthermore, unpublished studies often lacked sufficient methodological detail for quality appraisal, outcome data, and long-term follow-up, and the absence of peer review made it difficult to appraise internal validity in a standardised way

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Although current guidelines (ESH and ACC/AHA) recommend the measurement of arterial stiffness for personalized risk stratification of patients with hypertension, a better understanding of its pathophysiology is needed to define new targets for prevention and to bring us closer to healthy vascular aging

Statistical Analysis Statistical analysis was performed using SPSS version 19.0 (IBM, Armonk, NY, USA)

10.1371/journal.pone.0302650 151 ZhongG.ChenJ.LiY.HanY.WangM.NieQ.et al (2024)

USA 96 , 48204825 (1999)