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Comparisons between 2 values were made using an unpaired, 2-tailed Student t -test unless otherwise specified

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More accurate measurement of GSH concentrations and its flux across cell organelles and between tumor cells and their microenvironment will allow development of better tools for in silico exploration of therapeutic opportunities and deeper understanding of glutathiones many roles

An Atmospheric Control Unit allowed oxygen levels to be changed rapidly while detailed metabolic measurements could be made using the intracellular probes MitoXpress Intra and JC-1 using time-resolved fluorescence and fluorescence measurements, respectively

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