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Chronic sleep deprivation systematically leads to weight gain and metabolic imbalances and sleep deprivation decreases antioxidant levels in rats and humans, leading to oxidative stress (D'Almeida et al

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The rs7997012 CC genotype further suggests that pharmacodynamic sensitivity at the 5-HT2A receptor may be attenuated, reinforcing the need for rigorous outcome monitoring (e.g., systematic rating scales at 46 weeks) and timely adjustment of treatment if meaningful symptom reduction is not observed ( These scenarios illustrate how multigene profiles can refine initial drug choice (e.g., avoiding primary CYP-substrates in extremes of metabolism), starting dose, titration speed, and monitoring intensity

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See Additional file 7 for the GSEA enrichment plots for all seven datasets

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Lysophosphatidic Acid A natural essential element of the cell membrane

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Approximately 90% of ocular delivery dosage forms consist of conventional eye drop formulations

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TQ is a monoterpene benzoquinone compound synthesized in plants from -terpinene during secondary metabolism (279)

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