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For instance, Z-Arg-Arg-p-nitroaniline, Bz-Phe-Val-Arg-pNA, p Glu-Phe-Leu- p -nitroanilide and N-Cbz-L-Gln- p -nitrophenyl ester hydrolysis leads in solution to chromophores easy detectable at 405 nm ( 4 Bromelain as an emerging anticancer agent: Molecular mechanisms, signaling pathways and therapeutic targets To elucidate in detail the potential mechanisms of anticancer action, bromelain has been extensively studied in numerous studies ( in vivo in animal models and in vitro as a potential agent against several cancer lines such as gastrointestinal, colorectal, breast, mesothelioma, lung, hepatic, pancreatic, epidermoid, and melanoma ( Table 2 and Figure 1 )

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Human colonic biopsies were collected at the First Affiliated Hospital of Guangdong Pharmaceutical University