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Nanoparticleliver interactions: cellular uptake and hepatobiliary elimination

IFN- further enhances the expression of NKG2D on NK cells, which interacts with UL16-binding protein (ULBP1-6) and MHC class I chain-related proteins A and B (MICA/B) on tumor cells, enhancing the direct cytotoxicity of NK cells [58, 59]

You lose the benefit of the intact "master" molecule

Additionally, integrating biomarkerguided patient stratification (e.g., based on mitochondrial function or NTFs receptor status) into trial design may help identify subgroups most likely to benefit from axistargeted therapies

CRISPR/Cas9 library screening for drug target discovery

Pellissier et al