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[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Use of GLP-1 receptor agonists and occurrence of thyroid disorders: a meta-analysis of randomized controlled trials

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Supplementation of cystine restored mTORC1 signaling and treatment with rapamycin (a specific mTORC1 inhibitor) abolished the induction, providing evidence for the direct role of mTORC1 in the phosphorylation of p70S6K (T389) and S6 (S235/236)

In addition, other tissue metabolism also has obstacles, such as nervous system damage