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(1998) published in Disease Management and Clinical Outcomes found that GHK-Cu cream applied to thigh skin for 12 weeks improved collagen production in 70% of women treated, compared to 50% with vitamin C cream and 40% with retinoic acid

We then evaluated whether LCN2 ablation affects antioxidant defenses that counteract ferroptosis, focusing on the cystine/glutamate antiporter System Xc (encoded by Slc7a11/SLC7A11/xCT) and glutathione peroxidase (GPX4), which together mitigates oxidative stress by promoting cystine import and glutathione synthesis [11, 30]

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doi: 10.1016/j.mrgentox.2008.09.015 48 LinP

J Biol Chem 293:6259