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The extrinsic pathway is triggered by ligand binding (e.g., FAS, TNF-, TRAIL) to their receptors, activating FADD, which in turn activates caspase-8 and caspase-10, ultimately leading to apoptosis via caspase-3 and caspase-7 [33]

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Mallinson JE, Constantin-Teodosiu D, Sidaway J et al (2009) Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy

Catabolism of lipids is thus highly dependent on mitochondrial metabolism in the liver

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