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Alcohol Clin Exp Res 20(8):13521361 Zhang Z et al (2012) Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

It plays a vital role in the healthy functioning of many systems in the body, including the following: DNA (genetic material) synthesis Energy production (metabolism) Nerve cell health Neurological (brain) function Red blood cell (hemoglobin) formation Vitamin B12 plays a key role in the normal functioning of the brain and nervous system

The underlying disease mechanisms include immune activation, mitochondrial dysfunction, lipid homeostasis disorder, and metal ion imbalance (Tolosa et al., 2006

These cardiovascular adverse effects include first-dose bradycardia, atrioventricular conduction block and hypotension, and they must be cautiously considered when utilizing this drug for CIPN prevention and treatment [4]

doi:10.1126/science.289.5484.1567

On the other hand, it further exacerbates ferroptosis through changes to the metabolite profilesspecifically, reducing the production of anti-ferroptosis metabolites such as 5-HT and 3-HAA, and increasing the abundance of pro-ferroptosis metabolites such as LPS and TMAO