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Two studies that did not met our inclusion criteria, reporting 4 MD cases with complex I deficiency in muscle without a genetic diagnosis, showed improved maximal workload and muscle force under high fat diet [54, 55]

ATP Assay Kit, Calcium Ion Fluorescent Probe (Fluo-4 AM), 2, 7-dichlorodihydrofluorescein diacetate (DCFH-DA) and live (calcein-AM)/dead (propidium iodide, PI) dyes were purchased from Beyotime Institute of Biotechnology (China)

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