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doi: 10.1126/science.124.3220.484-a

Mechanistic studies have confirmed that its molecular action pathway involves the activation of soluble guanylate cyclase (sGC)-cyclic GMP (cGMP)-protein kinase G (PKG) signaling cascade, ultimately inducing pulmonary vascular smooth muscle relaxation ( 3.3 Feasibility of exercise intervention 3.3.1 Objectives and benefits of exercise intervention Exercise-mediated biochemical cascades regulate the levels of circulating inflammatory mediators and activate endogenous homeostasis maintenance mechanisms (Nemmar et al., 2018), and achieving free radical clearance by regulating the balance of the oxidative/antioxidative system (Rajizadeh et al., 2023)

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A lower Firmicutes/Bacteroidetes ratio (142), reduced counts of Lactobacillaceae (143), and altered abundance of several genera have been reported (144) including Eggerthella , Klebsiella , Flavonifractor , Lachnospiraceae (145, 146), Prevotella , Eubacterium, and Rhodococcus were significantly enriched, whereas Pseudobutyrivibrio and Dialister were decreased in SLE patients (147)

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