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The difference was more pronounced in VEROE6 cells (50-fold), followed by HUH7 cells (9-fold) and Caco2 (3-fold), while in Calu3 cells only Luc/Spike-C3 showed some low-level infection (maximum 250 relative luciferase units (RLU))

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Data availability The list of metabolites, normalized or not, are publicly available in the figshare repository ( All the images summarized in the Fig

Some of the points discussed in this article have been adapted from reviews by Dekant et al