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doi: 10.1371/journal.pone.0018532 418 Lopes-PacienciaSSaint-GermainERowellM-CRuizAFKalegariPFerbeyreG

The thioredoxin system (TrxR/Trx) maintains protein thiols in a reduced state by reducing oxidized proteins (particularly disulfide bonds) and regulates the activity of redox-sensitive transcription factors like NF-B [119]

SARS-CoV-2 encodes two of these viroporin proteins, E and ORF3a

Although singlet oxygen is a product of enzymatic and nonenzymatic reactions, the biological functions of 1 O 2 , compared to those of other ROS, are poorly understood

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Recent studies have demonstrated the inflammatory regulatory role of the mtDNA synthesis protein CMPK2, finding that CMPK2 can combine adiposity and obesity-related proteins (FTOs) in FLS to regulate synovial inflammation via the mtDNA-mediated cGAS/STING pathway, and that inhibition of the FTOCMPK2 axis attenuates disease progression (30)