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There's a small incidence of anaphylaxis using IV iron but most commonly we see a range of "hypersensitivity reactions" with intravenous iron which include, but are not limited to the following: hives, rashes, joint swelling and pain, fever, headache, chills flu-like symptoms, abdominal pain, diarrhea and constipation as well as muscle pain and cramping

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In-depth mechanistic studies revealed that ES penetrates the cell membrane by forming a complex with extracellular Cu2+, reducing Cu2+ to Cu+, and releasing highly reactive ROS in the mitochondria

However, the dosing regimen has to be adjusted to maximize concentration of glutathione in the blood and bioavailability studies are warranted prior to designing the treatment protocol

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