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showed percentages ranging from 53.6% to 82.3% of undiagnosed DPN among patients with painful diabetic neuropathy

However, human experiments confirmed that only obese Chinese male children/adolescents (5-14 years old) had significantly lower (20.3%) intra-cycle MOTS-C levels (22)

Vitamin B12 injection administered into the arm

Our data, consistent with the literature [32], show that chronic duration of therapy, higher cumulative metformin dose and concomitant PPI therapy (Table 1) increase the risk of vitamin B 12 deficiency

Results should be confirmed with a larger group and over a longer period of time 2

Goldberg DJ, Hornfeldt CS