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Meanwhile, multiple agents modulate inflammatory signaling cascades: Fangchinoline inhibits RAGENF-B, curcumol attenuates ROSAkt/mTOR (130), and gastronin, astragalus total saponins, and baicalin target the TLR4NF-B pathway (131)

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The supplement did not contain lipoic acid, and it did not affect levels of lipoic acid, so it appears that children were more likely to improve if they already had sufficient lipoic acid, whereas a lower level of lipoic acid seemed to be associated with less improvement