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Factors influencing ADME properties of therapeutic antisense oligonucleotides: physicochemical characteristics and beyond

The decrease in SAM levels leads to HCC cell proliferations, cell survival, and microvascular formation

Jan 2013;12(1):7-24

Yet, when standardized for body weight variations, the BMC to body weight ratio appeared consistent

Overall, 42 and 45 metabolites were identified in pHLS9 and HepaRG systems, respectively, with metabolite number increasing alongside alkyl chain length and heterocyclic substitution