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In apolipoprotein-E-knockout mice, exercise training (treadmill running, 6080% VO 2 max, 15 m/min, 1 h/day, 5 days/week, 1516 weeks) reduces the expression of ER stress proteins, BCL-2-associated X protein (Bax), and TXNIP/NLRP3 inflammasome cascades in the heart, diminishes NADPH oxidase p67 phox expression and superoxide production in coronary arterioles, while simultaneously elevating NO production and UCP2 expression in the heart [50]