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One proposed hypothesis, as yet untested, is that high-dose folic acid supplements cause depletion of the transport protein holotranscobalamin in serum, thus exacerbating B12 deficiency

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A 2024 study showed that copper peptide formulations activated this pathway, increasing expression of VEGF (vascular endothelial growth factor) and HGF (hepatocyte growth factor) both critical for follicle regeneration [3]

2016, 7:S57

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