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It is estimated that, since the 1970s, the incidence rate of liver cancer has tripled in Canadian men and doubled in Canadian women

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Whereas this might be the case for highly reactive soft electrophiles (e.g., NAPQI), weaker electrophiles (e.g., acrylamide, methyl acrylate) are unlikely to react spontaneously (non-enzymatically) with GSH [32], [44]

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Longitudinal changes of cerebral glutathione levels in patients with secondary progressive multiple sclerosis may reflect the clinical course of disease progression

Similarly, fluctuation in corticotropin-releasing hormone (CRH) which regulates the stress response predispose women to windows of vulnerability to mood disturbances and autoimmune disorders during key transitions in life including puberty, early menopause, immediately postpartum, and just prior to menstruation (PMS)