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The chromatographic separation was performed on an Agilent ZORBAX RRHD Extend 80 C18, 2.1 150 mm column (particle diameter 1.8 m) equipped with an Agilent ZORBAX SB-C8, 2.1 mm 30 mm guard column

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Buffers (Table 2) are added to parenteral formulations to adjust the pH [33, 36, 37] with the aim of optimizing solubility and stability, and are typically used in the 10100 mM range [33]

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