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These results suggest that systemic administration of acetaminophen metabolizes to AM404, which directly acts on spinal cord dorsal horn and induces analgesia

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Biochem Biophys Acta 1466:315327 Yamamoto BK, Zhu W (1998) The effects of metamphetamine on the production of free radicals and oxidative stress

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Apigeninidin induces apoptosis through activation of Bak and Bax and subsequent mediation of mitochondrial damage in human promyelocytic leukemia HL-60 cells