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TMA is a precursor to TMAO (Galland, 2014), which is oxidized after absorption by intestinal epithelium to form TMAO

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Comparative Clinical, Physiological, and Pathophysiological Outcomes of Revascularization Modalities and Intensive Lifestyle Medicine in Atherosclerotic Coronary Artery Disease Abstract Over the past two decades, evidence from randomized controlled trials has reframed the management of stable (chronic) coronary syndromes from a reflexively interventional paradigm toward one in which guideline-directed medical therapy and intensive lifestyle modification are recognized as central management strategies in many patients with stable disease