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Therefore, these values should be considered estimates that indicate qualitative trends rather than precise quantitative values

reported that heme levels and export were significantly increased in adipose tissue in T2DM patients and that the gene level of heme exporter (FLVCR1) was positively correlated with fasting blood glucose, suggesting that systemic glucose impairment during T2DM may be associated with heme export from adipose tissue [57]

The altered metabolites (Fig

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Cancer cells in tumors with IDH1 or IDH2 mutations show oncogenic activity by converting glutamine-derived -KG to 2-hydroxyglutarate (2-HG), which competitively inhibits -KG-dependent histone and DNA modification enzymes 27

Research indicates significant alterations in the expression profiles of multiple miRNAs in kidney tissues of DN patients and these changes participate in pathological processes including vascular inflammation, oxidative stress, and fibrosis by regulating downstream target genes