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Although ICI immunotherapy has been shown to have significant positive effects in some cancer patients, there is still evidence of drug resistance in many tumors, including GBM, due to tumor heterogeneity, low tumor-infiltrating T-cell (TIL) levels, loss of target antigens and off-target toxicity (89, 90)

Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia

These factors include exposure to sunburns, cuts, radiation, chemicals, and trauma (Rodrigues et al., 2017)

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