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In adults with growth hormone receptor deficiency, eight weeks of rhIGF-1 therapy significantly increased whole-body protein synthesis, decreased protein oxidation and increased lean body mass while reducing fat mass, demonstrating enhanced muscle anabolism and nutrient utilization in humans

Strategies have been developed to load drugs onto the surfaces of neutrophils [318, 319], making it a viable approach to couple particles containing bioactive peptides or proteins on the surface of neutrophils for tissue repair via targeted delivery

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conducted an experimental non-targeted LC/MS metabolomics analysis in patients with IBD, extracting and analyzing serum samples from both active and non-active cases, and found that most patients showed decreased serum tryptophan and tryptophan metabolites, as well as decreased ability to utilize outstanding amino acid (113)