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However it should be noted that the biological activities and therapeutic effects of polyphenols are also potentially mediated by their metabolites formed in the gut, liver, or gut microbiota, therefore demonstrating the complexity of polyphenols in this context [589,590]

Kluwer Academic Publishers, 49-67, 1998

officinalis significantly inhibits RANKL-mediated osteoclast differentiation in a dose-dependent manner and RANKL-induced phosphorylation of p38 and c-JUN N-terminal kinase