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Nivolumab + Ipilimumab for MSI-H/dMMR Metastatic Colorectal Cancer FDA Approval Date: April 8, 2025 The FDA approved nivolumab plus ipilimumab for adults and adolescents (12 years) with unresectable or metastatic MSI-H/dMMR colorectal cancer, converting nivolumab monotherapy from accelerated to regular approval

Funding The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article

Interestingly, the crystal structure of the SOCS2Elongin B/C complex revealed that the C-terminus of the SOCS box and the N-terminus of the extended SH2 subdomain (ESS) can interact and maintain the stability of the SH2SOCS box domain interaction (131)

10.1111/jdi.12376 107 WangY.WuH.DongN.SuX.DuanM.WeiY.et al (2021)

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Notably, C57BL/6 male mice that received sulforaphane in conjunction with depression-inducing lipopolysaccharide, exhibited lower depressive behaviours on the tail-suspension test and forced swimming test compared to those that did not receive sulforaphane (Zhang et al., 2017)