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doi: 10.1016/j.rvsc.2020.03.011 76 MionBOgilvieLVan WintersBSpricigoJFAnanSDuplessisMet al

Mechanistically, Nerandomilast alleviates the chronic inflammatory milieu of lung tissue by blocking PI3K/Akt/NF-B signaling and down-regulating pro-inflammatory mediators (e.g., IL-1, TNF-), thereby indirectly curbing inflammation-driven EMT activation ( Galunisertib is a highly selective inhibitor of transforming growth factor- receptor I (ALK5) that specifically targets the TGF-/Smad signaling cascade

Vitexin Protects Melanocytes from Oxidative Stress via Activating MAPK-Nrf2/ARE Pathway

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Potential off-target effects and drug interactions, requiring more extensive toxicological profiling

Rho-GTPases are important in maintaining intestinal tissue homeostasis, especially for intestinal epithelial cells and T cells