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Maskos, 2008)

RTAs often lack target engagement biomarkers or companion diagnostics, making it difficult to confirm whether they reach and modulate the intended ferroptotic pathways in vivo

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doi: 10.2147/IJN.S321984 Summary Keywords cancer immunotherapy, covalent organic frameworks, immunogenic cell death, immunosuppressive tumor microenvironment, photodynamic therapy Citation Zou Y, Chen M, Chen J, Wang W and Zheng X (2026) Covalent organic frameworks for cancer immunotherapy: mechanisms, applications, and prospects

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