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In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

Retrieved December 31, 2013

Kleele T, Rey T, Winter J, Zaganelli S, Mahecic D, Perreten Lambert H, et al

For most people, high-dose oral or sublingual supplements are effective

Monthly or even quarterly depot injections of GLP-1 agonists are in development