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Several studies documented higher incidence and lower age onset of ALS in high profile athletes, leading to the hypothesis that strenuous, repetitive exercise may represent an environmental risk factor to develop the disease (Scarmeas et al., 2002), supporting the hypothesis that heavy exercise could represent a suspected risk factor for ALS

As oxidative stress rises and beneficial bacteria decline, the intestinal barrier can weaken

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Mou et al., 2022)

Table 4 shows some DEGs from each functional category after acid shock at pH 3.0 (t = 1 h)