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According to Dr Aravinda, congenital diseases include Immerslund-Grsbeck illness, which causes severe vitamin B12 insufficiency, and genetic intrinsic factor abnormalities which can both lead to severe vitamin B12 deficiency

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Moreover, there are stratified factors that have been identified to be involved in the relationship between MTHFR and diseases, such as gender, age, and ethnicity 6,7,8,9

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The body needs enough intrinsic factor to absorb and reabsorb vitamin B 12 from the bile, the lack of which reduces the time needed to develop a deficiency