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Delayed height gain, underweight status, delayed puberty, and hormonal imbalances are commonly observed in untreated or poorly managed cases

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In mammalian systems, hm 5 C levels exhibit marked spatial heterogeneity, as demonstrated in the mouse brain [182]: High hm 5 C concentrations were identified in the brainstem, hippocampus, and cerebellum, while the hypothalamus and amygdala showed moderate levels, and the cerebral cortex displayed the lowest density

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