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Indeed, NMDA receptor inhibition in the prefrontal cortex increases extracellular glutamate that acts on AMPA and kainate receptors, which in turn stimulate dopamine release in the prefrontal cortex and striatum ([8] and references therein)

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Doseresponse considerations Moreover, no uniform doseresponse relationship was evident across escalating OTA levels, likely reflecting the heterogeneity of animal species, experimental settings, and exposure durations among studies

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Eberhardt J, Santos-Martins D, Tillack AF et al (2021) Autodock vina 1.2.0: new docking methods, expanded force field, and python bindings

These phytochemicals inhibit NF-B/STAT3 activation, which suppresses tumor growth and metastasis in certain models of breast and colorectal carcinomas